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  Vol. 128 No. 8, August 1992 TABLE OF CONTENTS
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Fluconazole Treatment of Cutaneous Cryptococcosis

Steven R. Feldman, MD, PhD; Alan B. Fleischer, Jr, MD; Steven D. Resnick, MD

Arch Dermatol. 1992;128(8):1045-1046.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REPORT OF A CASE

A 58-year-old man with a history of angina and glucose intolerance had a nonhealing, nonpruritic left forearm plaque that had slowly enlarged over a 6-month period (Fig 1). He denied any history of trauma at this site. He felt well otherwise and denied having a cough or headache. The lesion measured 4x5 cm, with a sharp border along the wristwatch band. The edematous, crusted, and pseudovesicular appearance suggested a variety of infectious and inflammatory diagnoses. The clinical differential diagnosis included acute neutrophilic dermatosis, blastomycosis, and atypical mycobacteria infection. A skin biopsy was performed, the specimen revealing marked epidermal hyperplasia, papillary edema, and numerous yeasts without inflammation (Figs 2 and 3). A fungal culture of the lesion yielded Cryptococcus neoformans. A chest roentgenogram showed no infiltrate or focal lesions, the complete blood cell count showed normal neutrophil and lymphocyte counts, the blood chemistry findings were normal, and . . . [Full Text PDF of this Article]


Author Affiliations



Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC; University of North Carolina, Chapel Hill



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