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Fluconazole Treatment of Cutaneous Cryptococcosis
Steven R. Feldman, MD, PhD;
Alan B. Fleischer, Jr, MD;
Steven D. Resnick, MD
Arch Dermatol. 1992;128(8):1045-1046.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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REPORT OF A CASE
A 58-year-old man with a history of angina and glucose intolerance had a nonhealing, nonpruritic left forearm plaque that had slowly enlarged over a 6-month period (Fig 1). He denied any history of trauma at this site. He felt well otherwise and denied having a cough or headache. The lesion measured 4x5 cm, with a sharp border along the wristwatch band. The edematous, crusted, and pseudovesicular appearance suggested a variety of infectious and inflammatory diagnoses. The clinical differential diagnosis included acute neutrophilic dermatosis, blastomycosis, and atypical mycobacteria infection. A skin biopsy was performed, the specimen revealing marked epidermal hyperplasia, papillary edema, and numerous yeasts without inflammation (Figs 2 and 3). A fungal culture of the lesion yielded Cryptococcus neoformans. A chest roentgenogram showed no infiltrate or focal lesions, the complete blood cell count showed normal neutrophil and lymphocyte counts, the blood chemistry findings were normal, and
. . . [Full Text PDF of this Article]
Author Affiliations
Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC; University of North Carolina, Chapel Hill
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