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Alain Hovnanian, MD; Angela M. Christiano, PhD; Jovni Vitto, MD, PhD

Arch Dermatol. 1993;129(12):1566-1570.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EPIDERMOLYSIS BULLOSA (EB) is a heterogeneous group of inherited skin diseases characterized by blistering of the skin and mucous membranes after minor trauma.^1-3 The genes responsible for the three groups of EB (EB simplex, junctional EB, and dystrophic EB [DEB]) have recently been identified, and some molecular defects within these genes have been characterized.^4,5 Specifically, EB simplex has been shown to arise from mutations in the keratin 5 and 14 genes^6-10; the genes encoding nicein/kalinin/epiligrin are the candidate genes in junctional EB¹¹; and both dominant and recessive forms of DEB (DDEB and RDEB, respectively) have been closely linked to the type VII collagen gene (COL7A1)^12-16 that encodes the major component of anchoring fibrils (AFs).^17,18 Biochemistry and molecular biology of basement membrane zone components involved in human diseases have been reviewed by Marinkovich¹⁹ in this issue of the ARCHIVES. This editorial focuses on the . . . [Full Text PDF of this Article]

Author Affiliations
Laboratoire de Biochimie et Génétique Moléculaire INSERM U. 91 Hôpital Henri Mondor 51 Av du Maréchal de Lattre de Tassigny 94010 Créteil, France; Department of Dermatology and Department of Biochemistry and Molecular Dermatology Jefferson Medical College Thomas Jefferson University Philadelphia, PA 19107

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