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Skin-Associated Lymphoid Tissue (SALT)-Related B-Cell Lymphoma (Primary Cutaneous B-Cell Lymphoma)A Concept and a Clinicopathologic Entity
Benvenuto Giannotti, MD;
Marco Santucci, MD
Arch Dermatol. 1993;129(3):353-355.
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The existence of primary cutaneous B-cell lymphoma (pCBCL), ie, non-Hodgkin's B-cell lymphoma primarily presenting in the skin without any clinically and/or instrumentally detectable extracutaneous localization, has been only recently accepted. Indeed, B-cell lymphomas in the skin have long been considered as a sign of progression and dissemination of lymph node disease, and thus as associated with a poor prognosis, even in the absence of clinically detectable extracutaneous lesions. Conversely, B-cell lymphoproliferative disorders characterized by good response to local treatment, absence of extracutaneous localization, and favorable prognosis have been generally considered as reactive processes, thus being defined as pseudolymphomas.1-4 The increasing use of immunohistochemistry5,6 and, quite recently, of DNA analysis7 in clinicopathologic studies dealing with primary cutaneous B-cell lymphoproliferative disorders made clear that a monoclonal restriction of the surface immunoglobulins (sIg) is present in a consistent part of these cases.8-11 Therefore, as monoclonal proliferations of B-cells, they
. . . [Full Text PDF of this Article]
Author Affiliations
II Department of Dermatology University of Florence Via della Pergola 58 1-50121 Firenze Italy; Institute of Morbid Anatomy and Histology University of Florence Viale G. B. Morgagni 85 50134 Firenze Italy
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