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Joseph A. Chorny, MD; Kenneth R. Shroyer, MD, PhD; Loren E. Golitz, MD
Department of Pathology; Departments of Dermatology and Pathology University of Colorado Health Science Center 4200 E Ninth Ave Denver, CO 80202

Arch Dermatol. 1993;129(9):1212.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recessive dystrophic epidermolysis bullosa (RDEB) is characterized by skin blistering and scarring with the potential for the development of secondary cutaneous squamous cell carcinomas (SCCs). We report a case of RDEB-associated cutaneous malignant melanoma and SCC that was negative for known human papilloma virus DNA sequences by the polymerase chain reaction.

Report of a Case.

A 22-year-old man with generalized scarring from RDEB underwent amputation of his hand for an SCC measuring 4x5x1 cm (Figure). A simultaneous biopsy of a nodule of the superior helix of the right ear was performed. Histopathologic examination of the ear nodule revealed a 3.2-mm-thick nodular melanoma (Clark's level IV). The tumor stained strongly using monoclonal antibodies with immunoperoxidase for S100 and HMB45 antigens. Despite living in Florida, Colorado, and Texas, the patient reportedly had little sun exposure. There was no family history of cancer. There was no record of a preceding nevus of the . . . [Full Text PDF of this Article]

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