This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Julia H. Cohen, MD; Stuart R. Lessin, MD; Benjamin R. Vowels, PhD; Bernice Benoit; William K. Witmer; Alain H. Rook, MD
Department of Dermatology Hospital of the University of Pennsylvania 3400 Spruce St Philadelphia, PA 19104

Arch Dermatol. 1993;129(9):1213-1215.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Among the clinical entities felt to result from biologically active agents produced by neoplasms is the proliferative skin disorder of Leser-Trélat. This syndrome is characterized by the rapid emergence of multiple seborrheic keratoses in association with an internal malignancy. Though traditionally associated with adenocarcinomas of the stomach, hematopoietic malignancies are the second most recorded neoplasm to be linked with the sign of Leser-Trélat.¹ Moreover, there have been several specific cases in patients with mycosis fungoides and Sézary syndrome.^2-4

In this report, we document an additional case of multiple seborrheic keratoses paralleling the evolution of Sézary syndrome and its response to a new combination treatment with interferon alfa and extracorporeal photopheresis.⁵ Our observation of the resolution of the sign of Leser-Trélat in concert with the induction of a complete remission of the cutaneous T-cell lymphoma, which is documented at the clinical and molecular level, is discussed.

Report of . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?