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Toby A. Maurer, MD; Michael E. Winter, PharmD; John Koo, MD
San Francisco, Calif

Timothy G. Berger, MD
Department of Dermatology, Ward 92 San Francisco General Hospital 1001 Potrero Ave San Francisco, CA 94110

Arch Dermatol. 1994;130(11):1455-1457.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Topical salicylate preparations have been used for years in the treatment of psoriasis. Toxic reactions, including nausea and vomiting, metabolic acidosis, confusion, coma, and death, have been reported.^1-4 We report a case of refractory hypoglycemia due to acute salicylate toxicity associated with topical salicylic acid (SA) used for the treatment of psoriasis. The risk factors associated with this unusual but potentially fatal complication of psoriasis treatment are reviewed.

Report of a Case.

A 79-year-old man was admitted for extensive psoriasis. His medical problems included hypertension, non-insulin-dependent diabetes, chronic atrial fibrillation, and acute renal failure. Medications included glyburide (2.5 mg twice a day), digoxin (0.025 mg daily), and diltiazam. The patient denied taking aspirin. The serum glucose concentration was normal at 4.4 µmol/L (80 mg/dL); the creatinine level was elevated to 172 µmol/L (1.9 mg/dL).

The patient's treatment consisted of a combination of UV light and increasing concentrations of crude . . . [Full Text PDF of this Article]

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