 |
|
Clearing of Melanoma In Situ With Intralesional Interferon Alfa in a Patient With Xeroderma Pigmentosum
Maria L. Chanco Turner, MD;
Allan N. Moshell, MD;
David W. Corbett, MD;
Jere B. Stern, MD;
Mark J. Roth, MD;
John DiGiovanna, MD;
Thomas D. Horn, MD;
Kenneth H. Kraemer, MD
Arch Dermatol. 1994;130(12):1491-1494.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
REPORT OF A CASE
The patient (XP1Be)1 is a 47-year-old, healthy woman with xeroderma pigmentosum (XP), complementation group C, who, from age 2 years, has had more than 200 nonmelanoma skin cancers, predominantly basal cell cancers. She had 34 primary melanomas: six were found to be minimally invasive while the rest were melanomas in situ (MIS). At the time of evaluation, she had 10 biopsyproven MIS remaining. The other melanomas had been surgically excised previously.
Examination revealed an alert, intelligent, cheerful, blind patient. Both orbits had been enucleated after infiltrating squamous cell carcinomas failed to respond to surgery and radiation therapy. On a background of pale, freckled, telangiectatic skin, she had seborrheic keratoses, nonspecific keratotic papules, angiomas, solar lentigos, and scars. Numerous 3- to 4-mm white-to-pink atrophic and hypertrophic scars from small excisions or desiccation and curettage of nonmelanoma skin cancers covered her body. There were also large, deep
. . . [Full Text PDF of this Article]
Author Affiliations
National Cancer Institute, Bethesda, Md (Drs Chanco Turner, Stern, Roth, DiGiovanna, and Kraemer); National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Md (Dr Moshell); US Naval Medical Center, Bethesda, Md (Dr Corbett); and The Johns Hopkins Medical School, Baltimore, Md (Dr Horn)
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
