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Pablo L. Ortiz-Romero, MD
Servicio de Dermatologia Hospital Universitario 12 de Octubre Ctra de Andalucia, Km 5400 28041 Madrid, Spain

Claudio Ballestin-Carcavilla, MD; Jose L. Lopez-Estebaranz, MD; Luis Iglesias-Diez, MD
Madrid, Spain

Arch Dermatol. 1994;130(12):1559-1560.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Different authors have showed the epidermal origin of amiloyd in lichen amyloidosis (LA) and macular amyloidosis (MA).¹ We examined eight consecutive patients suffering from LA, MA, or biphasic amyloidosis (BA) in a clinicopathologic study characterizing amyloid deposits with several monoclonal antikeratin antibodies and establishing immunohistochemical differences among the three disorders.

Patients, Materials, and Methods.

Biopsy specimens were taken from all patients and divided into two portions. Half of the specimen was formalin-fixed, paraffin-embedded, and processed for hematoxylin-eosin, Congored, and thioflavine T staining. Samples were scored as positive or negative for the presence of amyloid deposits in the epidermis; papillar, middle, or deep dermis; and perivascular or periadnexial area. The other half was snap frozen in liquid nitrogen and processed for immunohistochemistry (avidin-biotin complex technique, Table).

Results.

Patients 1 and 2 had MA, patients 2 through 6 had LA, and patients 7 and 8 had BA. Their mean age was . . . [Full Text PDF of this Article]

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