This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Sikina Rossi, MD; Margot Whitfeld, MBBS; Timothy G. Berger, MD

Arch Dermatol. 1995;131(1):24-26.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REPORT OF A CASE

A 46-year-old Hispanic homosexual man was seen because of persistent painful hyperkeratotic lesions of the right leg and left hip each greater than 2 cm in diameter (Figure 1). Results of laboratory investigations disclosed a CD4 cell count of 0.2x 10⁹/L. History disclosed Kaposi's sarcoma, bacillary angiomatosis, cryptococcal meningitis, Pneumocystis pneumonia, and disseminated Mycobacterium avium complex. Medications included dideoxyinosine, sulfamethoxazole and trimethoprim, fluconazole, clarithromycin, ethambutol, morphine, and diphenoxylate. Cultures taken from the lesions yielded varicella zoster virus (VZV). He had been treated with oral acyclovir (800 mg five times daily) with initial flattening of the lesions but without complete resolution. A subsequent viral culture of the lesions yielded VZV that was acyclovir resistant owing to a thymidine kinase deficiency. The skin biopsy specimen showed epidermal necrosis with multinucleated giant cells and intranuclear inclusions consistent with chronic VZV infection.¹ Local destruction of the lesions . . . [Full Text PDF of this Article]

Author Affiliations
University of British Columbia, Vancouver; San Francisco (Calif) General Hospital; University of California-San Francisco

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?