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Elia Roo, MD; Cristina Villegas, MD; Eduardo Lopez-Bran, MD; Esther Jimenez, MD; Pilar Valle, MD; Evaristo Sanchez-Yus, MD
Department of Dermatology Hospital Universitario San Carlos Zurbano 25 28010 Madrid, Spain

Arch Dermatol. 1995;131(2):226.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We appreciate the comments by Dr Cerroni concerning our article; we know of his expertise in the field of immunophenotyping of cutaneous lymphoproliferative disorders. The expression of some T-cell—associated antigens by B lymphocytes is a frequent and useful criterion to identify some B lymphocytes, both in frozen and in paraffin-embedded sections.

Let us supply some further histologic data. Our immunohistochemical studies were performed on paraffinembedded sections with the following antibodies: Mtl, UCHL1, L26, MB-2, and anti and anti light chains. More than 90% of lymphoid cells were positive for anti—T-cell antibodies (MT1 and UCHL1); less than 10% were positive forantiB-cell antibodies (126 and MB-2). Normal-appearing plasma cells, containing both and light chains, were scattered throughout the infiltrate, mainly in the periphery of the nodules. Histiocytic cells, not reactive with the above= mentioned antibodies, formed eccentrically situated groups within the nodules.

These data, and those previously mentioned, prompt us . . . [Full Text PDF of this Article]

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