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Anne Bouloc, MD; Jean-Michel Pawlotsky, MD; Valérie Choukroun, MD; Françoise Norol, MD; Jean-Paul Vernant, MD; Jean Revuz, MD
Créteil

Martine Bagot, MD, PhD
Department of Dermatology Henri Mondor Hospital 5 Ave du Maréchal de Lattre de Tassigny 94010 Cretéil, France

Arch Dermatol. 1995;131(7):853-855.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chronic graft-vs-host disease (GVHD) is a significant problem in patients who undergo bone marrow transplantation (BMT). It shares common clinical and histologic characteristics with lichen planus. The association of hepatitis C virus (HCV)-induced chronic hepatitis and lichen planus has been reported recently.¹ To evaluate the possible role of HCV in the pathogenesis of chronic GVHD, two studies were performed in the BMT unit of our institution.

Patients and Methods.Cohort Study.

One hundred twenty-six consecutive patients who underwent allogeneic BMT between January 1987 and December 1991, with more than 6 months of follow-up post-BMT, were analyzed retrospectively. The mean age was 31 years. Chronic GVHD was defined as previously.² Serum samples were obtained before and after BMT (mean delay, 11 months; [range, 6 to 54 months]). Anti-HCV antibodies were sought by a second-generation enzyme-linked immunosorbent assay (ELISA 2.0, Ortho Diagnostic Systems, Raritan, NJ) and a second-generation recombinant immunoblot . . . [Full Text PDF of this Article]

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