This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

New Lessons From Neurofibromatosis Type 1

Vincent M. Riccardi, MD

Arch Dermatol. 1995;131(8):944.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

FOR MANY years, students of the neurofibromatoses focused on the principle of neural crest origin of lesions of these disorders. It was as though characterizing them as neurocristopathies would reveal the keys to pathogenesis more quickly and more compellingly. On the other hand, these same students have learned not to be surprised by unexpected associations and correlations in neurofibromatosis type 1 (NF-1), whether at the clinical or molecular level. It turns out that the latter approach has been more fruitful. Associations that do not seem to fit at first have become more revealing as their basic biological and molecular mechanisms are now amenable to analysis. In this issue of the ARCHIVES, Zvulunov et al¹ focus on one set of associations in NF-1 that has fascinated me since the late 1970s: NF-1 and its association with juvenile xanthogranuloma (JXG), juvenile chronic myelogenous leukemia (JCML), or both.

See also page 904 . . . [Full Text PDF of this Article]

Author Affiliations
The Neurofibromatosis Institute 5415 Briggs Ave La Crescenta, CA 91214

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?