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Thomas Matthias Zollner, MD
Department of Dermatology University of Frankfurt am Main Theodor-Stern-Kai 7 D-60590 Frankfurt am Main, Germany

Sylvia Stracke, MD; Birgid Neumeister, MD; Burkhard Manfras, MD; Wolf-Henning Boehncke, MD; Bernhard Otto Boehm, MD; Reinhard Marre, MD
Ulm, Germany

Wolfram Sterry, MD
Berlin, Germany

Arch Dermatol. 1996;132(10):1247-1249.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Since 1989, an increasing number of patients with unexplained CD4⁺ T-lymphocyte depletion, but without evident human immunodeficiency virus (HIV) infection, have been described. This condition is now defined as idiopathic CD4⁺ T lymphocytopenia (ICL).^1,2

Report of a Case.

We describe a 73-year-old man suffering from sporotrichoid nodules on his right lower leg (Figure 1). Five of his 7 children died in their early childhood of cystic fibrosis. The patient and all other relatives were free of symptoms of cystic fibrosis. Analysis of the cystic fibrosis transmembrane regulator (CFTR) gene revealed the mutation F508 in the patient and 3 of 8 analyzed relatives, and another less common mutation was found in the patient's wife.³

Histological examination of a nodule showed a subcutaneous suppurative granulomatous dermatitis. Periodic acid—Schiff staining revealed fungal elements in hyphal form (Figure 2). Microbiological cultivation of biopsy specimens yielded growth of Exophiala jeanselmei and . . . [Full Text PDF of this Article]

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