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Hensin Tsao, MD, PhD; Klaus Busam, MD; Raymond L. Barnhill, MD
Boston, Mass

Jeffrey S. Dover, MD, FRCPC
Division of Dermatology New England Deaconess Hospital Harvard Medical School 195 Pilgrim Rd Boston, MA 02215

Arch Dermatol. 1996;132(10):1250-1251.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A well-documented but uncommon side effect of minocycline hydrochloride therapy is mucocutaneous pigmentation.¹ Although the exact nature of the pigment deposited is still controversial, melanin and iron appear to play important roles in creating the blue-gray discoloration.² Treatment for the complication has traditionally been cessation of drug use. We report the effective use of the Q-switched ruby laser in eliminating a case of minocycline-induced hyperpigmentation.

Report of a Case.

A 69-year-old man with a long history of rosacea began oral minocycline hydrochloride therapy (100 mg twice a day) in 1993. In April 1995, he presented with profound blue-gray pigmentation over the forehead, temporal area, preauricular area, and upper part of the cheeks. Small (<1 cm) blue-gray macules were also found on his shins. His sclera and teeth were spared.

Three areas on the shins were chosen for a therapeutic trial with lasers. A biopsy was performed on l . . . [Full Text PDF of this Article]

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