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Keith Allen Knoell, MD; Sandy S. Milgraum, MD; Mira Kutenplon
The University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School Piscataway, NJ 08854

Arch Dermatol. 1996;132(10):1251-1253.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Minocycline, a semisynthetic derivative of tetracycline that is used in the long-term treatment of many disorders, has been shown to occasionally cause a disfiguring cutaneous hyperpigmentation that may persist years after cessation of therapy.^1-3 To date, the precise mechanism of minocycline-induced cutaneous hyperpigmentation has not been fully elucidated; however, various histopathologic studies suggest that iron deposition,^1-5 increased melanization,^2,3,5 and/or deposits of minocycline degradation byproducts^1,2,5,6 may be associated with this condition.

The Q-switched ruby laser, which operates under the principle of selective photothermolysis at 694 nm, effectively targets melanocytic and blue-black chromophores with minimal disruption of surrounding cutaneous structures and has been successfully used in the treatment of a variety of lesions characterized by dense deposits of dark pigments.

We evaluated the efficacy of the Q-switched ruby laser in the treatment of persistent minocycline-induced hyperpigmentation associated with increased melanization.

Report of a Case.

A 59-year-old white woman . . . [Full Text PDF of this Article]

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