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Evaluation of 17 Consecutive Patients

Martina Kerscher, MD; Michael Meurer, MD; Christian Sander, MD; Matthias Volkenandt, MD; Percy Lehmann, MD; Gerd Plewig, MD; Martin Röcken, MD

Arch Dermatol. 1996;132(11):1280-1282.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REPORT OF A CASE

A 42-year-old woman who suffered for more than 2 years from disseminated localized scleroderma (LS) (Figure 1) markedly improved during treatment with psoralen with UV-A (PUVA) bath photochemotherapy with 8-methoxy-psoralen (8-MOP).¹ The 8-MOP was applied to the skin during a warm water bath, which was immediately followed by UV-A exposure. Clinical, histological, and ultrasound indications of LS (Figure 2) regressed almost completely during PUVA bath photochemotherapy in this and 2 other patients, 1 with disseminated LS and 1 with contractures caused by linear LS of the dorsal aspects of the left thigh and entire left leg.¹

THERAPEUTIC CHALLENGE

No single therapy produces uniform disease remission in LS.^2-6 A safe and effective therapy associated with the least potential complications is required.

SOLUTION

Since clinical regression of sclerosis was confirmed by ultrasound and histological evaluations, we considered PUVA bath photochemotherapy a promising novel therapeutic approach . . . [Full Text PDF of this Article]

Author Affiliations
Ludwig-Maximilians-Universität München, Munich, Germany

Dr Kerscher is now with the University of Bonn and Dr Lehmann is now with the University of Düsseldorf.

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