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Bruce R. Smoller, MD
Department of Dermatology and Pathology Stanford University School of Medicine 300 Pasteur Dr H2110 Stanford, CA 94305

Arch Dermatol. 1996;132(4):468.

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I read with interest the article by Resnick et al,¹ in which the authors attempt to group cases of limited acral cutaneous T-cell lymphoma into a single entity entitled "mycosis fungoides palmaris et plantaris." While this is certainly an admirable goal, I must object to the inclusion of several of their cases under such a designation, including a case report we published.²

Mycosis fungoides is defined as a neoplastic proliferation of CD4⁺ T-helper cells by most groups studying cutaneous T-cell lymphomas.^3-5 Our case was that of a cutaneous T-cell lymphoma limited to an extremity for longer than 30 years, which was characterized by CD8⁺, CD30⁺, CD4^- lymphocytes. This is not an immunophenotype that would ordinarily be seen in mycosis fungoides. In addition, almost half of all reported cases of Woringer-Kolopp disease (pagetoid reticulosis) are CD8⁺, CD4^- T-cell lymphomas. These cases are neoplasms derived from a different population of . . . [Full Text PDF of this Article]

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