This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Klaus F. Helm, MD
Division of Dermatology The Milton S. Hershey Medical Center The Pennsylvania State University College of Medicine Box 850 Hershey, PA 17033

Susan Bittenbender, MD
Rusell Localio Hershey

Dr Bittenbender is now with Hahnemann University, Philadelphia, Pa.

Arch Dermatol. 1996;132(4):471-472.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Recently, a number of studies have demonstrated genetic components in the development of malignant melanoma. A major melanoma risk allele has been localized to chromosome 9p.¹ Since multiple different types of malignancies frequently develop in cancer family syndromes, patients with melanoma may be at risk for having other tumors develop. Deletions in the region of 9p have also been found in patients with lung cancer and gliomas.^2,3 The defective gene may act as a tumor suppressor gene. Other oncogenes like p53 have also been shown to be expressed in some melanomas.⁴ The p53 oncogene has been implicated in numerous malignancies like squamous cell carcinoma and basal cell carcinoma.⁵ We retrospectively studied whether patients with melanoma had a higher incidence of neoplasms compared with a control population.

Methods.

Data on melanoma and other tumors were obtained from the tumor registry at Pennsylvania State University Hospital, Hershey. Three . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?