This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

CPT Thomas W. McGovern, MC; LTC Raymond J Enzenauer, MC; COL James E. Fitzpatrick, MC

Arch Dermatol. 1996;132(5):498-500.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

REPORT OF CASES

CASE 1

In November 1989, a 60-year-old white man with a 2-year history of chronic lymphocytic leukemia presented with a 1-week history of pain in both feet accompanied by progressive purpura and petechiae in the lower extremities. Purpura over both lateral malleoli and the right medial tibia ulcerated during the next 2 weeks (Figure 1, top). A skin biopsy specimen of a purpuric lesion revealed vascular occlusion with amorphous, eosinophilic material that was periodic acid Schiff—positive, diastase resistant, and phosphotungistic acid—hematoxylin negative. A mild perivascular infiltrate of lymphocytes and eosinophils was present. Special stains for organisms were negative.

The patient's cryoglobulin screen demonstrated a cryocrit of 0.3, 0.2, and 0.5 at temperatures of 4°C, 22°C, and 37°C, respectively. Cryoglobulin analysis revealed a monoclonal IgG-K type I cryoglobulinemia (CG). Despite two courses of chlorambucil (30 mg/d for 5 days every 4 weeks) and prednisone (20 to 60 mg/d), . . . [Full Text PDF of this Article]

Author Affiliations
USA; USA; USA; Fitzsimons Army Medical Center, Aurora, Colo

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?