This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Frederick S. Kaplan, MD

Arch Dermatol. 1996;132(7):815-818.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE EXPRESSION skin and bones conjures vivid thoughts of cachexia, starvation, and Third World geopolitics, but little consideration of a fertile field for scientific and medical investigation. In fact, few specialties in clinical medicine seem more disparate than those of dermatology and orthopedics.

An article in this issue of the ARCHIEVES documents, in 2 children, a rare and illustrative disease whose manifestations are specifically those of skin and bone.¹ The disorder, recently described as progressive osseous heteroplasia (POH), is characterized by dermal ossification in a mosaic distribution during infancy, followed by progressive focal ossification of connective tissue that includes subcutaneous fat, fascia, and skeletal muscle.^2,3

Most cases of POH appear sporadically, but siblings of several severely affected individuals have been discovered with apparent autosomal dominant transmission of a considerably more mild form of osteoma cutis.^2,4 The late consequences of heterotopic ossification in POH can be severe and include ankylosis of affected joints and . . . [Full Text PDF of this Article]

Author Affiliations
Division of Metabolic Bone Diseases and Molecular Orthopedics Department of Orthopedic Surgery The University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania Silverstein 2 3400 Spruce St Philadelphia, PA 19104

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?