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David P. Fivenson, MD
Department of Dermatology Henry Ford Hospital 2799 W Grand Blvd Detroit, MI 48202

John Schaffer
Cleveland, Ohio

Ghassan Saed, PhD
Detroit

Elsa R. Beck, DVM, PhD
Detroit

Gary S. Wood, MD
Cleveland

Arch Dermatol. 1996;132(7):841-842.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Cutaneous T-cell lymphoma (CTCL) is usually characterized by erythematous scaling patches, plaques, and tumors that can have a varied clinical course ranging from an indolent disease lasting for many years to a rapidly progressive fatal disease with extensive visceral involvement.¹ Recently, we have reported that canine CTCL mimics human CTCL ultrastructurally, genetically, and immunophenotypically,^2,3 and we propose that canine CTCL can be used as a model for the study of CTCL in humans.^3-5 Pancake et al⁶ have associated human mycosis fungoides (MF) and the adult T-cell lymphoma/leukemia syndrome with human T-cell lymphotropic virus type 1 (HTLV-1). There is also a report of reverse transcriptase activity in 1 dog with CTCL, suggesting a retroviral link.⁴ Herein we show that there is no detectable HTLV-1 or HTLV-2n DNA in a total of 10 cases of canine CTCL by either routine Southern blot analysis or by the polymerase . . . [Full Text PDF of this Article]

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