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Anthony P. Nikko; Cynthia J. Rutherford, MD
Dallas

Amit G. Pandya, MD
Department of Dermatology UT Southwestern Medical Center 5323 Harry Hines Blvd Dallas, TX 75235-9069

Arch Dermatol. 1996;132(8):978-979.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Sézary syndrome (SS), a leukemic form of cutaneous T-cell lymphoma (CTCL), is highly resistant to contemporary therapeutic modalities. A more aggressive form of disease that is even less responsive to therapy and characterized by transformation to large cell lymphoma develops in a substantial percentage of patients with SS. We describe a patient with SS that underwent lymphomatous transformation to large cell lymphoma. Treatment with the nucleoside analogue fludarabine phosphate resulted in complete remission for 14 months.

Report of a Case.

A 72-year-old white woman sought treatment because of an 11-month history of a chronic, relapsing, intensely pruritic eruption that had progressed to a generalized erythroderma. She had been treated with topical and systemic corticosteroids, oral psoralen with UV-A, etretinate, and hydroxyurea without substantial improvement. A physical examination revealed diffuse erythema and multiple, widespread, thin, scaly plaques. Erythema and keratoderma of her palms and soles were present. Laboratory data revealed . . . [Full Text PDF of this Article]

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