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What Is the Current Evidence for Causality?

Ingrid Warmuth, MD; Patrick S. Moore, MD, MPH

Arch Dermatol. 1997;133(1):83-85.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

KAPOSI SARCOMA (KS) has long fascinated epidemiologists, oncologists, and dermatologists. Its peculiar epidemiologic characteristics suggest an infectious cause and its mixed histogenesis and relatively indolent course in persons without human immunodeficiency virus (HIV) infection raise important questions about whether KS is a true cancer at all. This tumor's unique features led Oettle¹ to propose in the early 1960s that KS may be caused by a virus. Extensive studies by Giraldo and colleagues^2,3 on African-endemic and classic KS in the 1960s and 1970s suggest a herpesvirus, most probably cytomegalovirus, as the likely cause. Since then, a host of other agents, including most recently papillomaviruses,⁴ have been first proposed and then eliminated as candidate agents by careful laboratory studies.

Human T-cell lymphotropic virus type 1 (HTLV-1) belongs to the oncovirus subfamily of Retroviridae. In 1980, it was first isolated from a patient with an aggressive form of adult T-cell . . . [Full Text PDF of this Article]

Author Affiliations
Department of Dermatology College of Physicians and Surgeons Columbia University 630 W 168th St New York, NY 10032; New York

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