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Curtis A. Raskin, MD, PhD; John H. Tu, MD
Washington University School of Medicine 660 S Euclid, Box 8180 St Louis, MO 63110

Arch Dermatol. 1997;133(3):389.

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We would like to comment on the article by Kress et al¹ in a recent issue of the ARCHIVES that described, for the first time, an abnormality in keratin expression in a patient with Olmsted syndrome. The authors state that "AE1 is a monoclonal antikeratin antibody that has specificity for the acidic keratins, including keratins 5 and 14." Keratin 5 is a basic keratin that binds to the acidic keratin 14; therefore, keratin 5 should not directly interact with AE1.^2,3 The AE1 immunostaining pattern seen in Figure 5 in the article by Kress et al¹ may be ascribed to the presence of any of the acidic keratins, theoretically with or without their physiologically associated basic keratins.³ Although the decreased basilar AE1 staining suggests that there is defective processing and/or expression of keratin 14 in the basal keratinocytes, it provides no direct evidence for the presence of . . . [Full Text PDF of this Article]

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