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  Vol. 133 No. 6, June 1997 TABLE OF CONTENTS
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Latent Epstein-Barr Virus Infection Is Frequently Detected in Subcutaneous Lymphoma Associated With Hemophagocytosis but Not in Nonfatal Cytophagic Histiocytic Panniculitis-Reply

L. Jeffrey Medeiros, MD
Division of Pathology City of Hope National Medical Center 1500 E Duarte Rd Duarte, CA 91010-0269

Victoria Monterroso, MD
San Jose, Costa Rica

Arch Dermatol. 1997;133(6):788.

Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

We thank Iwatsuki and colleagues for their interest in our article.1 The goal of our study was to make the point that different types of T-cell lymphoma may initially present with involvement of subcutaneous tissue, of which a subset of cases are examples of subcutaneous panniculitic T-cell lymphoma. This view is shared by others, such as Burg et al.2 To illustrate our point we reported 2 cases. Patient 1 in our study was a woman who presented with multiple, nonulcerated, subcutaneous plaques associated with clinical and laboratory evidence suggestive of a hemophagocytic syndrome. Results of immunohistochemical studies revealed T-cell lineage without CD30 antigen expression. No evidence of Epstein-Barr virus (EBV) infection was detected using in situ hybridization methods to detect EBV RNA. The patient died 2 months after beginning chemotherapy. We interpreted this case as an example of subcutaneous panniculitic T-cell lymphoma. Patient 2 in our study was . . . [Full Text PDF of this Article]



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