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THE EXPERIMENTAL WHEAL PRODUCED ON NORMAL SKIN THROUGH INTERNAL CHANNELS

ABRAHAM WALZER, M.D.; MATTHEW WALZER, M.D.

Arch Derm Syphilol. 1928;17(5):659-686.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In an earlier paper on this subject,¹ we advanced a new method of production of wheals for the study of experimental urticaria. Previously, wheals had been produced only by the direct application of various agents to and into the skin. We, however, devised a method, based on an immunologic principle, by which wheals could be produced on the skin of almost any person through internal channels. It was shown that the injection of the serums of patients hypersensitive to certain food into the skin of a subject sensitized that site to the same food (Prausnitz and Küstner²), and that if the subject was fed the specific offending food, a wheal could be elicited at the passively sensitized site.

One of us (M. W.) has taken advantage of this technic, employing it as a means of demonstrating the absorption of certain undigested proteins from the gastro-intestinal tract. This has . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Jewish Hospital of Brooklyn, and from the Department of Bacteriology and Immunology, Division of Immunology, in Cornell University, and the New York Hospital.

Footnotes
Read in abstract at the annual meeting of the Medical Society of the State of New York, Section of Dermatology and Syphilis, at Niagara Falls, N. Y., May 11, 1927.

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