This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

THEIR RELATION TO DYSKERATOSIS

J. FRANK FRASER, M.D.

Arch Derm Syphilol. 1928;18(6):809-828.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The term dyskeratosis, as defined by Darier,¹ "represents a faulty development of the epidermis in the course of which a certain number of malpighian cells become isolated and differentiated from their fellows, undergoing an abnormal, premature and imperfect keratinization. These dyskeratotic cells are present in the layers of the epidermis, as far as in the horny layer, in the form of 'round bodies' (corps ronds), granules (grains), globes or corpuscles, with or without nuclei, easily distinguished from the still normal cells as well as from the parakeratotic cells."

In 1914, Darier¹ designated a group of dermatoses under the general heading of "the dyskeratoses." The classification was based on the assumption that the primary and characteristic histologic feature of the lesion in these diseases was dyskeratosis. The diseases classified as belonging to the group are:

1. Bowen's precancerous dermatosis.
   
2. Paget's disease of the nipple.
   
3. Dyskeratosis follicularis (Darier's disease).
   
4. Dyskeratosis follicularis (Darier's disease).
   
5. Molluscum contagiosum.
   

Author Affiliations
Assistant Professor of Clinical Medicine and Chief of Clinic, Department of Dermatology and Syphilology, Cornell University Medical College NEW YORK

Footnotes
Read at the Fifty-first Annual Meeting of the American Dermatological Association, Washington, D. C., April 30 to May 3, 1928.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?