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THEIR ABSORPTION AS MEASURED BY STUDIES ON EXCRETION

H. N. COLE, M.D.; NORA SCHREIBER, M.A.; TORALD SOLLMANN, M.D.

Arch Derm Syphilol. 1930;21(3):372-393.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Mercury has been used by the inunction route in the treatment of patients with syphilis almost since the first authentic reference to the disease. Mercurial ointments have been used in the treatment of persons with diseases of the skin since time immemorial; what then could have been more natural than that some investigator should have employed it experimentally when syphilis first appeared on the medical horizon? Thus one finds that among the earliest writings on syphilis the use of mercurial ointments is recommended. For example, among the ten incunabula on syphilis reviewed by Singer,¹ Schelling (1495), Grunpeck (1496), Torella (1497), Widman (1497) and Steber (1498) emphasize the value of this medication; though Leonicenus rather discredited its value. Naturally, these early writers had little rime or reason to their methods of therapy.

The Spanish syphilographer, Almenar, in 1501, seems to have been the first physician to employ a rational method . . . [Full Text PDF of this Article]

Author Affiliations
CLEVELAND

From the Departments of Dermatology and Syphilology and of Pharmacology of the School of Medicine of the Western Reserve University and of the Cleveland City and Lakeside Hospitals.

Footnotes
Submitted for publication, Aug. 27, 1929.

Read before the Section on Dermatology and Syphilology at the Eightieth Annual Session of the American Medical Association, Portland, Ore., July 11, 1929.

This work was done under the auspices of the Committee on Research in Syphilis. We also wish to acknowledge the financial support of the Lakeside Hospital and of a grant from the Council of Pharmacy and Chemistry of the American Medical Association and of a grant from the United States Pharmacopeia Committee.

The special ointments were for the most part obtained from Dr. Fullerton Cook, chairman of the Revision Committee of the "United States Pharmacopeia." Many of the specimens were prepared under the supervision of the Philadelphia College of Pharmacy and Science.

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