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II. EXPERIMENTS DEMONSTRATING THE ROLE OF THE SKIN, BOTH AS ORIGINATOR AND AS SITE OF THE HYPERSENSITIVENESS

MARION B. SULZBERGER, M.D.

Arch Derm Syphilol. 1930;22(5):839-849.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In my first paper¹ dealing with this subject, it was shown that guinea-pigs treated intradermally with a solution of neoarsphenamine develop hypersensitiveness of the skin to this drug. This shows itself in certain pigs by a spontaneous flare-up at the site of the intradermal injection and by a strong inflammatory reaction of hypersensitvity in almost all the animals tested later with intradermal injections of neoarsphenamine. Furthermore, intracardial injections of neoarsphenamine caused eruptions of the skin of varying degrees of severity in some of the hypersensitive animals, and focal reactions at the sites of previous intradermal injections could often be observed both after intracardial and after intradermal injections of the same drug. All of these observations confirmed the reports of W. Frei.²

It was suggested that all these phenomena of hypersensitiveness may be attributable to the various reactions that occur in different subjects, or at different times in the . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Dermatological Clinic of the University of Breslau; Geheimrat J. Jadassohn, Director.

Footnotes
Submitted for publication, May 19, 1930.

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