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GEORGE W. RAIZISS, Ph.D.; M. SEVERAC, M.D.

Arch Derm Syphilol. 1930;22(6):1031-1042.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The question of penetration of arsenic compounds into the cerebrospinal system owes its great importance to the fact that in the treatment for neurosyphilis and for trypanosomiasis of the central nervous system one does not today possess a remedy the efficacy of which even remotely approaches that displayed by the standard arsenicals in dealing with the same organisms in other parts of the body, before an invasion of the central nervous system has taken place. Clearly, what is required is a drug that will penetrate rapidly into the central nervous system in quantities sufficient to destroy the spirochetes or trypanosomes that are present there before serious injury to nerve tissue has occurred. Therefore, the problem would be resolved if the spirochetes or trypanosomes could be reached in the cerebrospinal fluid, that is, in the early stages of the invasion of the central nervous system. With this end in view, we . . . [Full Text PDF of this Article]

Author Affiliations
PHILADELPHIA

Footnotes
Submitted for publication, July 22, 1930.

Read before the Section on Dermatology and Syphilology at the Eighty-First Session of the American Medical Association, Detroit, June 25, 1930.

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