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POSTARSPHENAMINE DERMATITIS

JOSEPH EARLY MOORE, M.D.; SHUTAI T. WOO, M.D.; HARRY M. ROBINSON, M.D.; LESLIE N. GAY, M.D.

Arch Derm Syphilol. 1931;23(1):74-86.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is now generally believed that postarsphenamine dermatitis is the result of direct sensitization to arsphenamine, to the products of its metabolism or to a state of general allergic instability or hypersensitiveness not necessarily absolutely specific for arsphenamine. That it is a sensitization phenomenon seems clear from the fact that certain types of arsphenamine dermatitis, notably the exfoliative and vesicular rashes, practically always recur after any subsequent injection of the same arsphenamine product which originally produced them, no matter how small the dose (within therapeutic limits) or how long the interval between injections. Furthermore, there is some clinical evidence that certain instances of dermatitis may be actually drug specific in that, for example, neoarsphenamine or silver arsphenamine may be given, at first cautiously and finally in full dosage, to a patient who cannot take arsphenamine because of recurring rashes. These points are discussed in papers by Moore and Keidel¹ . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Syphilis Division and the Protein Sensitization Division of the Medical Clinic, the Johns Hopkins Hospital.

Footnotes
Submitted for publication, March 7, 1930.

Read at the Fifty-Third Annual Meeting of the American Dermatological Association, Cleveland, June 20, 1930.

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