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THE PRESENCE OF UNEVEN QUANTITIES OF BISMUTH IN OILY BULK SUSPENSION OF BISMUTH SALTS
H. N. COLE, M.D.;
KATHARINE I. HENDERSON, B.A.;
W. F. von OETTINGEN, M.D.;
TORALD SOLLMANN, M.D.
Arch Derm Syphilol. 1931;24(5):739-744.
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Our attention was first called to the possibility of unequal amounts of bismuth in measured doses of oily bulk bismuth suspension when working with tartroquiniobine. This is a suspension of the iodobismuthate of quinine and of sodium potassium bismuth tartrate in camphorated oil and has a metallic bismuth content of 6 cg. per two cubic centimeters. Because of the time required when doses are put up in separate ampules, as well as because of the expense, we used this preparation in 25 cc. amounts put up in wide-mouthed shallow bottles. The bottles were thoroughly shaken before the dose was removed; moreover, the suspension contained several glass beads to assist in more thorough mixing. At the bottom of the bottle we were occasionally surprised to find a heavy, thick, reddish deposit. This disturbing factor led us to examine several other bulk products that we were using, the potassium bismuth
. . . [Full Text PDF of this Article]
Author Affiliations
CLEVELAND
Footnotes
Submitted for publication, Feb. 8, 1931.
Drs. J. V. Ambler, Henry DeWolf and R. L. Howard helped in the collection of specimens.
This investigation has been supported by a grant from the Committee on Research in Syphilis, Inc.
From the Department of Dermatology and Syphilology and the Department of Pharmacology and Therapeutics, Western Reserve Medical School and the Cleveland City and Lakeside Hospitals.
Read at the Fifty-Fourth Annual Meeting of the American Dermatological Association, Toronto, Canada, June, 1931.
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