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GENERAL CONSIDERATIONS: LATENCY—A BIOLOGIC REACTION

MARTIN F. ENGMAN, M.D.; FREDERICK EBERSON, Ph.D.

Arch Derm Syphilol. 1921;3(4 PART 1):347-371.

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To give a clear idea of the meaning of latency, we must point to a few biologic facts in relation to the invasive stage of syphilis. After a given infection, when the virus is deposited on an abraded surface, the organisms begin to proliferate and are wafted quickly into the general circulation, as has been actually demonstrated by Brown and Pearce¹ and one of us.² The organisms continue to increase at the site of the lesion and probably within the body until the period of multiple systemic localization occurs. When the spirochetes are planted in the tissues and organs of the body, colonies are formed and through their growth and life cycle induce certain biochemical changes which may be exhibited in all organs; and, no matter where located, seem to stimulate the same cellular reaction. They arrive by way of the blood stream in these various organs and . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

Footnotes
Studies, reports and observations from the Dermatological Departments of the Barnard Free Skin and Cancer Hospital and the School of Medicine, Washington University, St. Louis, Mo., U. S. A., service of Drs. M. F. Engman and W. H. Mook.

Work done under grant of the U. S. Interdepartmental Social Hygiene Board, Washington, D. C.