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MAURICE KADIN, M.D.

Arch Derm Syphilol. 1938;37(5):787-796.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The toxic effects following the use of arsenical preparations in the treatment of syphilis have been known and reported in the literature since the introduction of arsphenamine by Ehrlich in 1910 and of neoarsphenamine in 1912. Hemorrhagic phenomena were first noted by Rumpel¹ in 1910 and by Leede² in 1911. Labbé and Langlois³ first drew attention to the importance of blood dyscrasia in 1919. Other reports of the toxic effects of arsenicals have been made by the Medical Research Council of Great Britain⁴ in 1922, by Kerl⁵ in Jadassohn's Handbuch in 1928, by Phelps and Washburn⁶ in 1930 and by Cole and his associates⁷ in 1931.

Farley⁸ in 1930 collected thirty-nine cases of damage to the bone marrow following the use of arsenicals in antisyphilitic therapy and added seven others, in only two of which there were findings of aplasia of all . . . [Full Text PDF of this Article]

Author Affiliations
CALUMET, MICH.

From the services of Drs. Leon Unger and Frederick Tice, Cook County Hospital.

From the department of pathology, Dr. R. H. Jaffé, director, Cook County Hospital. Dr. Jaffé, who died on Dec. 7, 1937, performed both autopsies and made the microscopic diagnosis.

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