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HERMAN CHARACHE, M.D.

Arch Derm Syphilol. 1939;40(2):185-191.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Multiple neurofibroma is a systemic disease easily diagnosed, little studied and seldom cured. In 13 per cent of the reported cases sarcomatous transformation has occurred. Skeletal changes have been demonstrated in a number of instances. Endocrine disturbances were noted in a series of cases. Hence, reporting a single case of neurofibromatosis with sarcomatous transformation and complete clinical investigation of the endocrine and skeletal system adds another link to the chain of events that may eventually lead to the complete understanding of the disease.

Fischer¹ in 1927 collected from the literature 59 cases of Recklinghausen's disease with sarcomatous transformation (13 per cent). Hosoi² reported 2 cases in 1931 and found the number in the literature increased to 65. There were 39 male and 24 female patients (in 2 cases the sex was not mentioned), a ratio of 1.6 to 1. At the time of the present writing the number . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Brooklyn Cancer Institute, Dr. Ira I. Kaplan, Director, Division of Cancer, Department of Hospitals, New York.

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