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JOSEPH J. ELLER, M.D.; SHIRLEY WOLFF

Arch Derm Syphilol. 1939;40(6):900-923.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Because of the systemic and local effects of the cutaneous application of various medicaments, the permeability and absorptivity of the skin are of particular importance to the dermatologist.

As far back as 1809 Mussey¹ proved that after topical application of certain drugs to the unbroken skin these drugs were found in the urine, and in 1901 Reilly² reported therapeutic effects after cutaneous application of such substances as belladonna, mercury, pilocarpine and cod liver oil and also the presence in the urine of salicylic acid, turpentine, guaiacol, creosote and phenol.

It has been demonstrated³ that substances soluble in oil are more readily absorbed through the unbroken skin than those soluble in water. Zondek⁴ reported that drugs in solvents such as alcohol, ether, benzine and chloroform are more rapidly absorbed and in greater amounts than those incorporated in an oily base. He also reported that estrogenic substances in . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

Footnotes
Read at the Sixty-Second Annual Meeting of the American Dermatological Association, Inc., Monte-Bello, Quebec, Canada, June 3, 1939.

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