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II. THE APPARENT SEPARATION OF THE SKIN-REACTIVE FACTOR FROM THE THERAPEUTIC PRINCIPLE IN TRICHOPHYTIN

SAMUEL M. PECK, M.D.; ARTHUR GLICK, M.D.; EDWARD WEISSBARD

Arch Derm Syphilol. 1941;44(5):816-836.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous communication¹ it was shown that Trichophyton gypseum was capable of producing a more alkaline p_H in Sabouraud's bouillon when grown on a medium with an initial p_H of 4.0 to 8.0. At an initial p_H of 9.0 to 10.0 the organism acidified the medium. There was occasionally acidification in buffered solutions which had an initial p_H of 7.0. At the end of variable periods of growth, approximately seventy-five to eighty days, the hydrogen ion concentration would finally become stabilized at a p_H of 8.3 to 8.6.

We were able to demonstrate in experiments embodied in a recent paper² that the component of trichophytin capable of eliciting a positive reaction to a cutaneous test was found in the bouillon itself as well as in the pellicle of a culture in Sabouraud's bouillon.

A number of observers have maintained that this skin-reactive . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Laboratories and Service of Dr. Isadore Rosen, Mount Sinai Hospital, and from the Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital.

Footnotes
Read in a symposium on Superficial Fungous Infections at the Sixty-Fourth Annual Meeting of the American Dermatological Association, Inc., New Orleans, April 10, 1941.

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