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REPORT OF SIX CASES

ORLANDO CAÑIZARES, M.D.; GEORGE E. MORRIS, M.D.

Arch Derm Syphilol. 1941;44(5):873-877.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The most serious complication of lymphogranuloma venereum observed is cicatrizing proctitis, which up to the present time has defied all methods of therapy. In some cases of this condition there has been improvement from thermal response obtained by the intravenous injection of Frei antigen, and recently promising results have been reported due to the efficacy of sulfanilamide and sulfathiazole (2-[paraaminobenzenesulfonamido]-thiazole) in these cases. Such therapeutic methods, however, are of value in a limited number of cases. It occurred to one of us (O. C.) that sulfaguanidine (sulfanilylguanidine), because of its specific action on the intestinal tract, might be of value.

Sulfaguanidine is a guanidine derivative of sulfanilamide which is characterized by its lack of absorbability in the gastrointestinal tract. This property permits one to obtain a relatively high effective concentration of the drug in the intestines, and thus the bacteriostatic action of the drug can be utilized here. Because of . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK; BOSTON

From the Department of Dermatology and Syphilology of the Third (New York University) Medical Division, Bellevue Hospital, service of Dr. Frank C. Combes.

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