
MASSIVE ARSENOTHERAPY IN EARLY SYPHILISREPORT OF SIXTY CASES IN WHICH NEOARSPHENAMINE WAS GIVEN
LUIS PRUNES, M.D.;
HEVIA P. HERNAN, M.D.
Arch Derm Syphilol. 1942;45(5):894-896.
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Since 1938 we have treated 60 syphilitic patients with neoarsphenamine in massive doses by the drip method. This paper refers chiefly to the immediate results of the treatment, as no follow-up studies have been made. The small number of reactions found in this series is worthy of mention.
Our technic is somewhat different from that followed by other authors. We inject by the drip method 1.5 Gm. of the arsenical dissolved in 250 cc. of double-distilled water. This requires about four hours. The injection is given on three consecutive days, a total amount of 4.5 Gm. of neoarsphenamine in 750 cc. of water being administered. A week after the last treatment a dose of 0.9 Gm. of the drug in 10 cc. of water is injected by the syringe method. The total amount of neoarsphenamine is then 5.4 Gm.
The 60 patients were all men varying from 22 to 35
. . . [Full Text PDF of this Article]
Author Affiliations
SANTIAGO, CHILE
From the Department of Dermatology and Syphilology, Hospital San Vicente de Paul, University of Chile, service of Dr. Luis Prunes.
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