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MANNER OF GROWTH: HISTOLOGIC STUDY OF WHOLE TUMOR SECTIONS

RICHARD L. SUTTON, Jr., M.D., F.R.C.S. (Edin.)

Arch Derm Syphilol. 1942;46(1):1-39.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

As a carcinoma grows, it expands laterally as well as in depth. Starting in known cancerous tissue near the middle of a lesion and moving radially outward, one must reach eventually an external region where all epithelium is known to be normal; hence transition zones must exist. My study concerns these zones where neoplastic and normal epithelium lie close together. The question is considered whether there occurs intergradient transition of cell type between obviously normal and obviously neoplastic cells or, alternatively, whether the normal cells are of one kind, the neoplastic ones of another kind and their spacial relation merely juxtaposition. Does "progressive cancerization" of normal epithelium occur at the boundary of a growing carcinoma?

MATERIALS AND METHODS

My material consists of whole tumor sections of some sixteen hundred cutaneous lesions. Most of the tumors were excised along with margins of normal skin by means of the actual cautery. Fixed . . . [Full Text PDF of this Article]

Author Affiliations
Assistant Professor of Dermatology, University of Kansas School of Medicine, Kansas City, Kan. KANSAS CITY, MO.

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