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JOSEPH MANDELBAUM, M.D.; LEO SCHLESSINGER, Ph.D.

Arch Derm Syphilol. 1942;46(3):431-442.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

It is generally conceded that vitamin A can be absorbed through the skin.¹ However, the only direct evidence for this consists of such animal experiments as have recently been reported by Helmer and Jansen² and by Eddy and Howell³; in the case of the intact human skin the evidence is more meager. Mackie and Eddy⁴ found a rise in the vitamin A level of the blood following the application of cod liver oil to the skin in chronic ulcerative colitis with poor intestinal absorption.

In order to test whether physiologically significant absorption can take place through the human skin, we performed dietary experiments on 17 young men.⁵ During the course of dietary vitamin A depletion, ointments containing vitamin A were applied to the skin of the subjects; the status of vitamin A nutrition was studied by means of dark adaptation measurements. The Hecht-Shlaer instrument⁶ . . . [Full Text PDF of this Article]

Author Affiliations

From the Department of Ophthalmology, Long Island College of Medicine.

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