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DAVID I. MACHT, M.D.

Arch Derm Syphilol. 1942;46(5):635-642.

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Cutaneous reactions are among the commonest toxic manifestations following administration of sulfanilamide and its derivatives, and as therapy with these drugs expands new toxic effects of this type are revealed. Certain of these compounds, particularly sulfathiazole,¹ appear to be more liable than others to induce dermatoses. Such reactions, however, have been described as occurring after administration of all the compounds. Thus, cyanosis, jaundice, erythema and dermatitis have been observed, and even scarlatiniform, morbilliform and purpuric eruptions may develop after treatment with sulfanilamide.² Acute exfoliative dermatitis with fatal outcome following the administration of sulfathiazole was described by Weinstein and Domm.³ Loveman and Simon⁴ noted erythema nodosum after sulfanilamide therapy. Vesicular eruptions were mentioned by Menville and Archinard.⁵ Other dermatoses occurring after sulfanilamide therapy were described by Tedder.⁶ Among the graver dermatologic lesions following the administration of these chemotherapeutic agents are eruptions of a pemphigoid type. . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Pharmacological Research Laboratory, Hynson, Westcott & Dunning, Inc.

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