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BIOLOGIC FALSE POSITIVE REACTIONS FOR SYPHILIS ASSOCIATED WITH HYPERPROTEINEMIAPRELIMINARY REPORT
LEONARD CARDON;
DONALD H. ATLAS, M.D.;
EDWARD ARON, M.D.;
MATTHEW J. BRUNNER, M.D.;
S. LLOYD TEITELMAN, M.D.;
JOSEPH BUNATA
Arch Derm Syphilol. 1942;46(5):713-720.
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The problem of the false positive reaction to a serologic test for syphilis is of great importance, especially with the advent of routine serologic tests in premarital examinations and selective service examinations and in connection with the antisyphilis campaign of the United States Public Health Service.
A false positive reaction may be either technical (due to laboratory variations) or biologic. The biologic type of false positive reaction is rarely encountered in normal persons (1 in 4,000); when it does occur it is thought to be due to the presence of a reagin-like substance which has recently been isolated from lower animals.1
This report is concerned with the more frequent type of biologic false positive reaction, that which has been reported for persons with diseases other than syphilis, viz., yaws (100 per cent), leprosy (40 to 80 per cent), malaria (100 per cent at some time during the infection) and
. . . [Full Text PDF of this Article]
Author Affiliations
CHICAGO
Attending physician, Cook County Hospital, and associate attending physician, Mount Sinai Hospital.
Formerly Josiah Macy Jr. Fellow in Medicine, Northwestern University Medical School; associate attending physician, Cook County Hospital.
From the Department of Medicine of the Northwestern University Medical School, the departments of Tuberculosis, Pathology and Medicine of the Cook County Hospital and the Robert B. Preble Memorial Laboratory.
Footnotes
Aided by a grant from the Josiah Macy Jr. Foundation.
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