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E. WILLIAM ABRAMOWITZ, M.D.; MARJORIE R. MATTICE, M.S.; ISADORE BOTVINICK, M.D.

Arch Derm Syphilol. 1943;47(2):175-184.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For almost two decades sodium thiosulfate has been accepted as the drug of choice in the treatment of arsenical dermatitis. Although dissenting opinion has existed throughout this period, it has never achieved widespread attention. More recently, however, the literature has emphasized the scarcity of evidence favoring the use of this drug. Chargin,¹ in particular, has voiced the doubt of an important group of dermatologists as to the value of sodium thiosulfate for any of the manifestations of arsphenamine toxicity.

One of the reasons given for thinking that sodium thiosulfate is beneficial in arsenic poisoning is based on Osborne's studies² of the behavior of certain crystals in the skin which he believed to be arsenic trisulfide. Montgomery and Waisman³ stated the belief that their investigations confirmed Osborne's findings. These crystals have been noted by others⁴ in the tissues both of normal persons and of persons with arsenical . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK; BETHESDA, MD.

From the Skin and Cancer Unit and the Department of Medicine of the New York Post-Graduate Medical School and Hospital.

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