 |
|
CI. HISTOCHEMISTRY OF PEMPHIGUS LESIONSWITH SPECIAL REFERENCE TO BULLOUS FORMATION
R. C. MacCARDLE, Ph.D.;
J. P. BAUMBERGER, D.Sc.;
W. C. HEROLD, M.D.
Arch Derm Syphilol. 1943;47(4):517-545.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
In this investigation, the problem of pemphigus was approached by a study of certain physiochemical and histochemical factors concerned in the production and properties of the characteristic lesion of this disease, a blister.1 Attempts were made to induce formation of artificial blisters in pemphigus skin by injection of fluids under pressure. The cohesive property of unaffected skin from patients with pemphigus was estimated by the use of measured weights, and the proteins of blister fluids were studied polarographically. Finally, the tissue minerals of unaffected pemphigus skin and of lesions were investigated by microincineration and spectrographic analysis. Cantharides blisters and areas showing Nikolsky's sign were also studied histochemically. Thus, an attempt was made to correlate various factors in the developmental stages of blister formation.
The clinical picture of pemphigus is striking, being characterized by insidious or rapid onset, usually in an adult, of bullous or vesicobullous formations on the skin
. . . [Full Text PDF of this Article]
Author Affiliations
ST. LOUIS
Footnotes
Drs. M. F. Engman Sr. and E. V. Cowdry suggested this study. Studies, observations and reports from the Barnard Free Skin and Cancer Hospital and the Anatomical Laboratory, Washington University School of Medicine.
Research Associate at the Barnard Free Skin and Cancer Hospital and Visiting Professor of Cytology at Washington University School of Medicine, on leave from the Department of Physiology, Stanford University.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
