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REPORT OF TWO HUNDRED AND EIGHTY TREATMENT COURSES WITH MAPHARSEN ALONE AND FIVE HUNDRED AND FORTY-NINE TREATMENT COURSES WITH MAPHARSEN COMBINED WITH FEVER

EVAN W. THOMAS, M.D.; GERTRUDE WEXLER, M.D.

Arch Derm Syphilol. 1943;47(4):553-568.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In 1941 we made a first report¹ on the rapid treatment of early syphilis by a course of diurnal injections of mapharsen, either alone or combined with fever therapy. By June 1942 in Bellevue Hospital 829 such courses had been given. As 47 of those were retreatments of patients who either had not been cured by their first course or had been reinfected, we treated a total of 782 patients. Of these, 479 were male and 303 female, and 462 were Negroes, 283 white persons, 35 Puerto Ricans and 2 Chinese.

METHODS OF TREATMENT AND CHOICE OF PATIENTS

Originally we set out to give every patient a total of 1.2 Gm. of mapharsen. As we reported, we did not administer the drug by the intravenous drip method introduced by Chargin, Leifer and Hyman.² Instead, we gave 0.06 Gm. of mapharsen intravenously every morning and evening for ten days. . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Department of Dermatology and Syphilology, New York University College of Medicine, and the Department of Dermatology and Syphilology, Third Medical Division (New York University), Bellevue Hospital.

Footnotes
This study was aided by grants from the United States Public Health Service and the American Committee on Research in Syphilis.

Miss Lena Taucci, R.N., gave invaluable assistance in the care of the patients. Dr. Henry Laven observed and followed the patients after therapy.

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