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PRELIMINARY REPORT

CAPTAIN I. ARTHUR MIRSKY; LEON GOLDMAN, M.D.

Arch Derm Syphilol. 1943;48(2):161-163.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Investigations of some aspects of dermatology have been hampered by the lack of an animal whose skin reacts to various irritants with the production of bullae. The guinea pig, which has been employed frequently for studies of eczema, will occasionally acquire subcorneal, intraepidermal (commonest) and subepidermal (rarest) vesicles. These are predominantly microscopic in size and arranged in long fissures, the latter apparently being due to the structure of the skin of the guinea pig. That these vesicles cannot be produced regularly is indicated by Bloch's studies with "primin," an antigen extracted with ether from the fresh leaves of the primrose (Primula obconica).¹ Furthermore, because of their size and shape and the rapidity with which they dry, the contents of vesicles on the skin of the guinea pig are not readily available for analysis.

Goldblatt² described an infectious, polymorphous eruption in guinea pigs which had as its most characteristic . . . [Full Text PDF of this Article]

Author Affiliations
MEDICAL CORPS, ARMY OF THE UNITED STATES; CINCINNATI

From the May Institute for Medical Research, the Jewish Hospital.

Footnotes
Released for publication by the Air Surgeon, the Gas Casualties Committee and the Advisory Committee on Scientific Publications of the National Research Council, all of which assume no responsibility, other than censorship, for the contents of the article.

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