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Arthur W. Grace, M.D.
Brooklyn.

Arch Derm Syphilol. 1943;48(6):659.

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To the Editor:—Dr. Heisel and his collaborators¹ state that "the originators of the test [used] a 7 mm. papule as a minimal positive [Frei] reaction. . . ." In the report which introduced chick embryo antigen (lygranum) as a material for the Frei test² it was noted that "the upper limit of the diameter of non-specific papules produced by these materials [lygranum antigens and control] was 5 mm." In the table accompanying that report it is clear that a papule 6 mm. in diameter was regarded as a positive reaction. Support has been given to the selection of this size of papular reaction when lygranum is used as the minimum which can be called positive by the observation³ that in 24 persons in whom the diameter of the papule of the Frei reaction was 6 mm. and who either presented clinical manifestations which could be regarded as lymphogranulomatous or . . . [Full Text PDF of this Article]

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