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VI. OINTMENTS CONTAINING CHRYSAROBIN

ERNEST A. STRAKOSCH, M.D., Ph.D.

Arch Derm Syphilol. 1944;49(1):1-7.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Chrysarobin was introduced into pharmacology by Balmanno Squire.¹ It was first found in cavities of the trunk of Andira araroba, a tree which grows in Brazil, in the Portuguese colony of Goa and elsewhere. The substance is crystalline, is tasteless and odorless, is slightly soluble in water, slightly soluble in alkalis (1: 385) and partially soluble in fats and turns brown when exposed to the air. It belongs to the group of so-called ``anthraglycosides'' and has the following formula:

Senna, rhubarb, cascara, aloe and emodin are closely related drugs. Emodin, for instance, is a trioxymethylanthraquinone, C₁₅H₁₀O₅, while chrysarobin is formed from chrysophanic acid, C₁₅H₁₀O₄, in the following way:

An alkaline solution of chrysarobin exposed to the air turns into chrysophanic acid. Attfield² in 1875 analyzed chrysarobin, or "Goa powder" as it was called in those days, and found . . . [Full Text PDF of this Article]

Author Affiliations
MINNEAPOLIS

From the Division of Dermatology and Syphilology, University of Minnesota, H. E. Michelson, M. D., Director, and the Department of Dermatology and Syphilology Minneapolis General Hospital, S. E. Sweitzer, M.D., Chief.

Footnotes
The third condensed part of a thesis submitted to the faculty of the Graduate School of the University of Minnesota in partial fulfilment of the requirements for the Degree of Doctor of Philosophy in Dermatology and Syphilology.

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