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II. THE VALUE OF PETROLATUM, ANHYDROUS WOOL FAT AND OTHER BASES IN PERCUTANEOUS ABSORPTION OF TOPICALLY APPLIED COTTONSEED ALLERGEN

ABRAHAM WALZER, M.D.; SAMUEL S. SACK, M.D.

Arch Derm Syphilol. 1944;49(6):427-431.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In a previous communication¹ it was demonstrated that proteins, such as cottonseed, when applied topically are absorbed through the skin of human beings and of monkeys. In that study a site on the skin of the subject to be tested was passively sensitized to cottonseed antigen. After twenty-four to forty-eight hours, the antigen, suspended in a grease base, was rubbed in at another cutaneous site. The development of a wheal at the sensitized site marked the entrance of detectable amounts of antigen into the circulation.

The serum for sensitization was obtained from a patient strongly sensitive to cottonseed and with an extremely high titer of reagins for this antigen (1: 512 by the dilution method of Coca and Grove²). The serum was used in a dilution of 1:4 in human subjects and undiluted in monkeys. From 0.05 to 0.1 cc. was injected intracutaneously for local passive . . . [Full Text PDF of this Article]

Author Affiliations
BROOKLYN

From the Department of Dermatology and Syphilology and the Department of Allergy of the Jewish Hospital of Brooklyn.

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